Painful, pruritic, indurated, erythematous plaque, Painful, pruritic, indurated, erythematous plaque with minute papules inferior to ecchymoses at the, Sixty-year-old woman (patient 1) 24 h after initiation of topical steroid treatment; the, Pruritic, painful, erythematous, indurated plaque, Pruritic, painful, erythematous, indurated plaque at vaccine site in a 44-year-old woman (patient, Erythematous, pruritic, painful, indurated plaque, Erythematous, pruritic, painful, indurated plaque in a 33-year-old woman (patient 3) 7 days, MeSH The swelling typically goes down in about two to 11 days. Delayed large local reactions to mRNA-1273 vaccine against SARS-CoV-2. Reactions that occur immediately after vaccination, or within a few hours, could be rare allergic reactions that require prompt medical attention, she added. Spikevax is also available as two adapted . Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission. In order to improve the traceability of biological medicinal products, the name and the batch number of the administered product should be clearly recorded. 2023 Feb 20:1-4. doi: 10.1007/s13691-023-00598-7. Urticaria was the next most common type of skin reaction associated with the Moderna vaccine. It will also have the potential to develop vaccines targeting a range of. The expiry date refers to the last day of that month. The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. There was also one person who had a delayed reaction after the second dose only. The Covid-19 vaccine is one example of how mRNA can be used. Published 2021. DOI: https://doi.org/10.1016/S2665-9913(21)00309-X. Management of suspected and confirmed COVID-19 (SARS-CoV-2) vaccine hypersensitivity. Unable to load your collection due to an error, Unable to load your delegates due to an error. J Prim Care Community Health. The federal government has granted companies. Moderna said people without insurance will be able to get its COVID vaccine at no cost after the U.S. government bows out. A shipping pallet may include up to 198 cases. Some who . News. [A red and swollen arm after vaccination for covid-19]. How well it works: Moderna's initial Phase 3 clinical data in December 2020 was similar to Pfizer-BioNTech'sat that point, both vaccines showed about 95% efficacy for prevention of COVID-19. Keep this leaflet. By contrast, 244 (0.8%) developed a delayed skin reactiondefined as a skin reaction that appears eight or more days laterafter getting their first dose, and 68 (0.2%) developed a delayed skin reaction after getting their second dose. If you have itching, swelling, or tenderness at the injection site in the days after getting either dose of the vaccine, don't panic. The vaccine works by causing the body to produce protection (antibodies) against the virus that causes COVID-19. Of the 414 reactions documented, 83% occurred in patients vaccinated with the Moderna vaccine and 17% in patients who received the Pfizer vaccine. an abnormal one at injection site), Injection site paraesthesia (abnormal skin sensations at injection site), Injection site pruritus (severe itching at injection site), Injection site urticaria (rash of round, red welts on the skin at injection site), Injection site vesicles (fluid- or air-filled cavity or sac at injection site), Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain), Joint range of motion decreased (disease of joint movement), Leukocytosis (increased white blood cells), Local reaction (reaction of any substance at the site of use), Lung consolidation (a condition whereby the lung tissues solidify because of the accumulation of solid and liquid material in the air spaces), Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung), Lymphadenitis (inflammation or enlargement of a lymph node), Lymph follicular hypertrophy (an increase in the size of the lymph node follicles), Lymphoedema (localized fluid retention and tissue swelling), Malaise (a feeling of general discomfort or uneasiness), Maternal exposure before pregnancy (use of substance before pregnancy), Maternal exposure during pregnancy (use of substance during pregnancy), Mechanical urticaria (urticaria is triggered by mechanical shearing forces e.g. Symptoms may include: hives swelling wheezing or trouble breathing Some people get a rash at the injection. Copyright 2023 Elsevier Inc. except certain content provided by third parties. The registry is supported by the American Academy of Dermatology and the International League of Dermatologic Societies. . Shingrix Second Dose: Everything You Need to Know, Delayed large local reactions to mRNA-1273 vaccine against SARS-CoV-2, Delayed localized hypersensitivity reactions to the Moderna COVID-19 vaccine: a case series, COVID arm: delayed hypersensitivity reactions to SARS-CoV-2 vaccines misdiagnosed as cellulitis, Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine: supplementary appendix, Incidence of cutaneous reactions after messenger RNA COVID-19 vaccines. Written informed consent for publication was obtained from the patients. Audio will be available later today. Careers. A randomized, double-blind, placebo-controlled phase III clinical trial to evaluate the efficacy and safety of SARS-CoV-2 vaccine (inactivated, Vero cell): a structured summary of a study protocol for a randomised controlled trial. Thank you, {{form.email}}, for signing up. March 2021. doi:10.1056/NEJMoa2035389, Johnston MS, Galan A, Watsky KL, Little AJ. N Engl J Med. If you get the Moderna COVID-19 vaccine, there is a small chance that you could develop a skin reaction. Talk to your doctor, pharmacist or nurse before you are given Spikevax if you: There is an increased risk of myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the lining outside the heart) after have been vaccination with Spikevax (see section 4). Most of the reactions were mild and resolved on their own. and transmitted securely. Who can get a COVID-19 vaccine Everyone aged 5 (on or before 31 August 2022) and over can get a 1st and 2nd dose of the COVID-19 vaccine. J Prim Care Community Health. If you miss a scheduled injection, you may not be fully protected against COVID-19. doctor. V-safe is a new voluntary smartphone-based tool that uses . He joined MedPage Today in 2007. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine: supplementary appendix. We report 3 cases of COVID arm, 2 of which were mistaken for cellulitis. 2021;12:215013272110244. doi:10.1177/21501327211024431, Baden L, El Sahly H, Essink B, et al. Spikevax will be given to you as two 0.5 mL injections. If you have itching, swelling, or tenderness at the injection site in the days after getting either dose of the vaccine, don't panic. Symptoms of COVID arm include: itching, which can be intense a red or discolored rash that varies in size from quarter-sized to very large in some instances, the rash may spread to your hands or. Clinicians can distinguish SARS-CoV-2 vaccine reactions from cellulitis by the time of onset (approximately a week vs 5 days), by the lack of progression of symptoms, and resolution over 4 to 5 days. Severe cases of COVID arm may be treated with topical steroids. However, the reactions' appearances can vary. Given the considerable potential for confusion, the researchers called for increased awareness of these skin reactions to help avoid needless diagnostic testing and treatment. Madrid 28002. COVID-19 vaccines protect against the SARS-CoV-2 virus only, so it's still important to keep yourself healthy and well. Additionally, five people died after receiving a jab from an. One dose (0.25mL) contains 50 micrograms of messenger RNA (mRNA) (embedded in SM-102 lipid nanoparticles). These conditions can develop within just a few days after vaccination and have primarily occurred within 14 days. Caroline Tien is a journalist with degrees in English and biology. Find out about the different types of COVID-19 vaccines, how they work, the possible side effects, and the benefits for you and your family. While unsightly and uncomfortable, the reactions usually resolve within a few days and do not pose any long-term health risks. If side effects such as pain and/or fever are troublesome, they can be treated by medicines for pain and fever such as paracetamol. A booster dose (0.25 mL) of Spikevax may be given at least 3 months after the second dose in Published 2021. Please include "Moderna COVID-19 Vaccine EUA" or "Moderna COVID-19 Vaccine, Bivalent EUA", as appropriate, in the first line of box #18 of the report form. To update your cookie settings, please visit the Cookie Preference Center for this site. No other type of reaction occurred in more than 1%-2% of patients after either dose. Accessed April 28, 2021. doi: 10.1002/ccr3.6317. Pendlebury GA, Oro P, Haynes W, Merideth D, Bartling S, Bongiorno MA. Following vaccination, you should be alert to signs of myocarditis and pericarditis, such as breathlessness, palpitations and chest pain, and seek immediate medical attention should these occur. The vaccine will be available to people aged 12 and older as a booster. Do not throw away any medicines via wastewater or household waste. The Centers for Disease Control and Prevention (CDC) now recommends that all individuals 5 years old who have completed a primary COVID-19 vaccine series (including those who already received booster doses with monovalent vaccines) receive a single booster dose with one of the bivalent vaccines at least two months after the last vaccine dose; bivalent booster recommendations for children . Moderna COVID-19 vaccine for children aged 6 months to 5 years: information for parents and guardians - 09092022 - Lao. We use some essential cookies to make this website work. A few cases of capillary leak syndrome flare-ups (causing fluid leakage from small blood vessels (capillaries) resulting in rapid swelling of the arms and legs, sudden weight gain and feeling faint, low blood pressure) have been reported following vaccination with Spikevax. Q:. This will allow quick identification of new safety information. The centre will offer NHS patients access to Moderna's COVID-19 vaccines that can protect against multiple variants. Opens in a new tab or window, Share on LinkedIn. Some reports may have incomplete information. How to treat COVID-19 vaccine injection site pain. Spikevax vials are multidose. Lipid SM-102 (heptadecan-9-yl 8-{(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino}octanoate), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (PEG2000 DMG). eCollection 2022 Oct. Bose P, Goenka U, Moitra S, Majumdar S, Goenka MK, Sen SG. COVID-19 Resource Centre This site needs JavaScript to work properly. They have been observed more often after the second dose compared to the first dose, and more often in younger males. Spikevax must not be mixed with other vaccines or medicinal products in the same syringe. COVID Arm: Delayed Hypersensitivity Reactions to SARS-CoV-2 Vaccines Misdiagnosed as Cellulitis. The doses are administered 28 days apart, and the vaccine trains the immune system to fight against future. Tel: 0800 085 7562. Please enable it to take advantage of the complete set of features! Paseo de Europa, 50 She has previously written for publications including Insider and Cancer Health. COVID-19 vaccine-induced cellulitis and myositis COVID-19 vaccine-induced cellulitis and myositis Cleve Clin J Med. Unable to load your collection due to an error, Unable to load your delegates due to an error. feeling faint or light-headed changes in your heartbeat shortness of breath wheezing swelling of your lips, face, tongue or throat hives or rash nausea or vomiting stomach pain Talk to your doctor. Doctors from. National Library of Medicine But patients will have to use the . COVID arm: delayed hypersensitivity reactions to SARS-CoV-2 vaccines misdiagnosed as cellulitis. This vaccine contains polyethylene glycol/macrogol (PEG) as part of PEG2000-DMG. eCollection 2022 Sep. Rodrguez Y, Rojas M, Beltrn S, Polo F, Camacho-Domnguez L, Morales SD, Gershwin ME, Anaya JM. The study is based on data from the CDC and the FDA. Shafie'ei M, Jamali M, Akbari Z, Sarvipour N, Ahmadzade M, Ahramiyanpour N. J Cosmet Dermatol. Successful Treatment of Delayed Localized Necrotizing Inflammatory Myositis After Severe Acute Respiratory Syndrome Coronavirus 2 mRNA-1273 Vaccine: A Case Report. Reactions to the Moderna COVID-19 vaccine usually happen within 4 hours of injection. This publication is available at https://www.gov.uk/government/publications/regulatory-approval-of-covid-19-vaccine-moderna/information-for-uk-recipients-on-covid-19-vaccine-moderna, Spikevax dispersion for injection Eur Rev Med Pharmacol Sci. From April, another bivalent COVID-19 vaccine will be available after the Australian Technical Advisory Group on Immunisation (ATAGI) approved Moderna's second Omicron-specific vaccine. 28703. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Madrid 28002 Moderna COVID-19 6 5 : . Since the launch of their covid-19 vaccines, Moderna and Pfizer have accumulated more than $100bn (83; 94) in global revenues from salesmore than 20 times the World Health Organization's biennial budget in 2020-21.1 2 3 Yet for a vaccine that is estimated to cost $1-3 per dose to manufacture, both Moderna and Pfizer have announced plans to charge more than $110 a dose in the US this . Eight days after getting injected with Moderna's Covid-19 vaccine, Hoang noticed her arm felt itchy. Guidance and regulation See section 4. you are allergic to the active substance or any of the other ingredients of this vaccine, listed in, have previously had a severe, life-threatening allergic reaction after any other vaccine injection or after you were given Spikevax in the past, have a very weak or compromised immune system. 8600 Rockville Pike Erythematous, pruritic, painful, indurated plaque in a 33-year-old woman (patient 3) 7days after first dose of vaccine. N Engl J Med. Adults who had 2 doses of Moderna were about 94% less likely to become ill from COVID-19 than people who did not get the vaccine. National Library of Medicine https://www.hhs.gov/immunization/basics/types/index.html. Epub 2022 Jun 21. A new study finds some of them, including COVID toes, a measleslike rash and shingles also can be rare, and thankfully brief, side . All rights reserved. The Centers for Disease Control and Prevention lists injection . Federal government websites often end in .gov or .mil. 1 Injection site pain, redness, or swelling Both the Moderna vaccine and the Pfizer vaccine may produce a reaction around the area on your arm where you got your shot. We saw the reactions on different skin tones but did not see any reaction on dark skin," Saff says. Among them, 2 people (0.0%) have Cellulitis staphylococcal. No serious reactions were reported. stroking or scratching the skin), Menstrual disorder (disease of menstrual cycle), Menstruation delayed (late menstruation cycle), Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability), Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition), Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation), Micturition urgency (urgency to pass the urine), Mobility decreased (ability to move is reduced), Monoplegia (a paralysis of a single limb), Mood swings (an extreme or rapid change in mood), Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness), Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. Cardiovascular symptoms, including faintness, syncope, altered mental status, palpitations, and hypotension. Spikevax should be administered by a trained healthcare professional. The chances of any of these side effects occurring after vaccination differ according to the specific vaccine. See this image and copyright information in PMC. Although we cannot exclude the possibility that the onset of vasculitis following vaccination was coincidental, striking similarities between these three patients argue for pathogenic causality. Before Is the COVID Vaccine Safe for People With Lung Cancer? WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. They give you the best protection against COVID-19. Antibiotics are medications that kill bacteria. This means that there is more evidence to come about this vaccine. Bookshelf Received vaccine (at least 1 dose) 312 (94.8%) Moderna 122 (39.1% . Frequency of the most common manifestations of local injection-site reactions, by dose, were swelling (18% and 15%), erythema (18% and 20%), and pain (24% and 18%). . Studies suggest that delayed skin reactions occurring days or a week after the shot may affect fewer than one in 100 people. Please enter a term before submitting your search. 2022 Jan;33 Suppl 27(Suppl 27):58-60. doi: 10.1111/pai.13631. For the primary series, Spikevax should be administered as two 0.5 mL (100 microgram) doses for individuals 12 years of age and older. In a study published in the NEJM in February, 2021, the investigators reported that 12,765 (84.2%) of the 15,168 participants who had received the vaccine rather than the placebo developed an immediate skin reaction after receiving their first dose of the vaccine. Both the Pfizer and Moderna vaccines are approved for ages 6 months and older. The rest of this document, including information about storage and handling, can be found in the PDF. While immediate reactions to the COVID-19 vaccines are common, these reports raised awareness that delayed skin reactions can also show up days to weeks after a Moderna shot. HHS Vulnerability Disclosure, Help Unlike cellulitis that tends to progress, or worsen over time, symptoms of skin reactions to COVID-19 vaccines tend to not progress, according a few case reports of vaccine reactions misdiagnosed as cellulitis that were published in the Journal of Primary Care & Community Health. This vaccine has been given conditional approval. While information on effects on pregnancy or the newborn baby after vaccination during the first trimester is limited, no change to the risk for miscarriage has been seen. Interleukin-1 and interleukin-6 inhibition compared with standard management in patients with COVID-19 and hyperinflammation: a cohort study. Access the latest 2019 novel coronavirus disease (COVID-19) content from across The Lancet journals as it is published. Anti-SARS-CoV-2 mRNA vaccine in patients with rheumatoid arthritis. In the NEJM letter, the researchers described how and when the skin reaction manifested in people between the ages of 31 and 61the majority of whom were White and female. You can help by reporting any side effects you may get. GC, GDL, SC, RP, FC, and LD took clinical care of patients, obtained data, and contributed to drafting the manuscript. As the Times notes, not only did Moderna make roughly $36 billion in sales from COVID-19 vaccines worldwide, the company also received $10 billion in taxpayer funding to help develop and test the . by Caffarelli C, Liotti L, Bianchi A, Bottau P, Caimmi S, Crisafulli G, Franceschini F, Paglialunga C, Saretta F, Mori F. Pediatr Allergy Immunol. If you miss an appointment, arrange another visit as soon as possible with your doctor, nurse, or pharmacist. See the end of section 4 for how to report side effects. Accessibility Cutaneous adverse reactions following COVID-19 vaccinations: A systematic review and meta-analysis. A few patients developed pernio/chilblains, better known as "COVID toes." Rebecca Saff, MD, PhD, another lead author of the NEJM report and allergy fellowship director of the allergy and clinical immunology unit in the division of rheumatology, allergy, and immunology at Massachusetts General Hospital, tells Verywell that in the trial, "adverse events, including local adverse symptoms, were solicited for the seven days after the vaccine was given and unsolicited for 28 days after the vaccine, meaning that many of the more mild reactions may have been missed if they were after day seven.". Opens in a new tab or window, Visit us on TikTok. COVID-19 - Recent advancements in identifying novel vaccine candidates and current status of upcoming SARS-CoV-2 vaccines. If you get the Moderna COVID-19 vaccine, there is a small chance that you could develop a skin reaction. Moderna COVID-19 vaccine generates long-lasting immune memory At a Glance People who received low doses of the Moderna COVID-19 vaccine had strong immune memories of the virus six months after being fully vaccinated. This includes any possible side effects not listed in this leaflet. COVID-19 mRNA Vaccine (nucleoside modified). doi: 10.1093/ofid/ofac499. The registry data included a total of eight cases of pernio/chilblains, three each after the first dose of both vaccines and two after the second Pfizer vaccine dose. 2021 Oct 7;114(6):424-425. doi: 10.1093/qjmed/hcab043. If you are concerned about a side-effect it can be reported directly via the Coronavirus Yellow Card reporting site or search for MHRA Yellow Card in the Google Play or Apple App Store and include the vaccine brand and batch/Lot number if available. It is recommended to get the second dose 28 days after the first dose to complete the vaccination course. Once the viral vector enters the body, immune cells then recognise . The registry added to a recent report of zoster flare as a skin reaction associated with COVID vaccination. Calle del Prncipe de Vergara 132 Plt 12 Local injection-site reactions occurred in 54% of patients after the first Moderna dose and 70% after the second dose. If you are immunocompromised, you may receive a third dose of Spikevax. The registry showed a total of 10 flares, five after a first dose of Moderna vaccine, one after an initial dose of Pfizer vaccine, and four after the second Pfizer dose. The authors noted that it's possible that redness gets overlooked or may not be as obvious on dark skin. The vaccine must be administered intramuscularly. The AstraZeneca vaccine is an example of a viral vector vaccine. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Dermatopathology (Basel). It is given to adults and children aged 6 years and older. Do not drive or use machines if you are feeling unwell after vaccination. Delayed large local reactions occurred after 15% of first doses and after 18% of second doses. Source Reference: McMahon DE, et al "Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases" J Am Acad Dermatol 2021; DOI: 10.1016/j.jaad.2021.03.092. 2021 Apr 13;22(1):276. doi: 10.1186/s13063-021-05180-1. Clipboard, Search History, and several other advanced features are temporarily unavailable. Kimberly Blumenthal, MD, lead author of the NEJM paper and co-director of the clinical epidemiology program in the division of rheumatology, allergy, and immunology at Massachusetts General Hospital, tells Verywell that the skin reactions can be as large as almost 20 centimeters, taking up most of the upper arm. However, the areas can also be much smaller. headache, muscle pain, joint pain. The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review. The most common manifestations of localized injection-site reactions were swelling (44% after the first dose, 68% after the second), erythema (49% and 67%), and pain (35% and 59%). Individuals should be observed by a healthcare professional for at least 15 minutes after vaccination. MeSH Keep this vaccine out of the sight and reach of children. Do not puncture the vial more than 20 times. Spikevax contains elasomeran, a molecule called messenger RNA (mRNA) with instructions for producing a protein from the original strain of SARS-CoV-2, the virus that causes COVID-19. A review of 414 skin reactions associated with the Moderna and Pfizer vaccines showed a variety of rashes, eruptions, and injection-site inflammation. The vaccine comes ready to use once thawed. COVID vaccines that are related to Vulval cellulitis: Vulval cellulitis in Moderna COVID Vaccine; Vulval cellulitis in Pfizer BioNTech Covid Vaccine; Vulval cellulitis in Johnson and Johnson Covid Vaccine Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. American Medical Association. doses of 0.25 mL can be delivered. Or visit Moderna COVID-19 Global. Hypersensitivity reactions to vaccines in children: from measles to SARS-CoV-2. Iqbal Yatoo M, Hamid Z, Parray OR, Wani AH, Ul Haq A, Saxena A, Patel SK, Pathak M, Tiwari R, Malik YS, Sah R, Rabaan AA, Rodriguez Morales AJ, Dhama K. Hum Vaccin Immunother. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). A third dose may be given at least 1 month after the second dose to individuals 12 years of age and older (0.5 mL, 100 micrograms) and children 6 through 11 years (0.25 mL, 50 micrograms) who are severely immunocompromised. Why vaccines go into your upper arm and not up your nose The first COVID-19 jabs . COVID-19 vasculitis and novel vasculitis mimics. Bookshelf Opens in a new tab or window, Share on Twitter. Spikevax uses a substance called messenger ribonucleic acid (mRNA) to carry instructions that cells in the body can use to make the spike protein that is also on the virus. "Ice can also be helpful for the swelling and pain at the site.". 2006;1172-1191. Information about storage, expiry, and use and handling are described in the section intended for healthcare professionals in the PDF. In addition, you can report side effects to ModernaTX, Inc. at 1-866-663-3762. Typical side effects include pain at the injection site, fever, fatigue, headache, muscle pain, chills and diarrhoea. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Mechanisms of coronavirus cell entry mediated by the viral spike protein. It is recommended to administer the second dose 28 days after the first dose. For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder. Moderna COVID Vaccine and Cellulitis staphylococcal - a phase IV clinical study of CDC and FDA data Summary: Cellulitis staphylococcal is reported only by a few people who get Moderna COVID Vaccine. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. There were 7 SAEs among 6 participants in the vaccine group (appendicitis, cellulitis, cellulitis orbital, type 1 diabetes mellitus, appendicitis, pyelonephritis and urosepsis). Sixty-year-old woman (patient 1) 24h after initiation of topical steroid treatment; the left arm showed a dramatic decrease in erythema and swelling. 2021;157(8):1000. doi:10.1001/jamadermatol.2021.2114. not provide full immunity to COVID-19 in people who are immunocompromised, and you should Like all medicines, this vaccine can cause side effects, although not everybody gets them. Not uncommonly, skin reactions were accompanied by systemic effects, including fatigue, myalgia, headache, fever, arthralgia, nausea, and chills. You may need to read it again. Among those who had a skin reaction after the first dose, 11 people also had a similar reaction after their second dose. Interleukin 1alpha: a comprehensive review on the role of IL-1alpha in the pathogenesis and treatment of autoimmune and inflammatory diseases. This publication is licensed under the terms of the Open Government Licence v3.0 except where otherwise stated.
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